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Just Breathe – A natural protocol to halt progression and improve symptoms of Parkinson’s, ME/CFS and Fibromyalgia

Dr. Bill Comiskey ND

Over six million people suffer from Parkinson’s Disease worldwide.  Parkinson’s is a neurodegenerative disorder which is characterized by motor symptoms including tremor, rigidity, slowness of movement, constipation and balance problems.  Non motor symptoms include loss of sense of smell, anxiety, depression, fatigue, pain and sleep problems.  Although drugs such as Levodopa are helpful, they do not stop the progression of the disease or damage.

The treatment is based upon the hypothesis that the disease leads to the death of neurons through its interaction with the intracellular metabolism of thiamine. This action can be blocked by the administration of high doses of thiamine combined with cofactors and IMST. The neurons, once no longer burdened by the primary cause of the disease, restart their activity and this leads to the improvement of most symptoms.  The therapy thus limits the degeneration of the nervous system which continues to work efficiently when freed from the limitations posed by the disease.

Thiamine and magnesium are essential cofactors in enzymes that preside over energy production.  Thiamine deficiency plays a huge part in autonomic dysregulation and is at the core of mitochondrial dysfunction.  Thiamine is a primary rate-limiting cofactor that is central to oxidative metabolism. All illness begins and ends with respiratory insufficiency and disturbed oxidative metabolism.  High calorie malnutrition, chronic stress, toxins and genetic defects disturbs oxidative metabolism. High calorie malnutrition, diets high in sugars and processed foods loaded in environmental chemicals but deficient in actual nutrients induce hypoxia (low oxygen) and thiamine deficiency.  Most if not all medications and vaccines damage the mitochondria and reduce oxidative metabolism.

Magnesium is required to change thiamine from its free form to the active form called thiamine pyrophosphate (TPP). Without sufficient magnesium, supplemental or consumed thiamine remains inactive and basically useless. This means that magnesium deficiency can cause a functional thiamine deficiency.

Alzheimer’s disease is the most common form of dementia.  Thiamine levels and the activity of thiamine dependent enzymes are reduced in the brains and peripheral tissues of patients with the disease.

Fibromyalgia is a disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep, memory and mood issues. Researchers believe that fibromyalgia amplifies painful sensations by affecting the way your brain and spinal cord process painful and nonpainful signals. Around 4 million people in the U.S. are living with fibromyalgia.

There are several biochemical findings in FMS which are similar to those seen in thiamine deficiency, and a few lines of research indicate that there may be a problem with thiamine processing or utilization at the cellular level. Thiamine also appears to dampen neuroinflammatory responses in brain cells, which may help to explain its calming and analgesic effects in people with ongoing inflammatory issues. 

Researchers are just beginning to understand that symptoms of fibromyalgia (and other conditions such as ME, CFS) could be the clinical manifestation of a thiamine deficiency due to a dysfunction of the active transport of thiamine from the blood to the mitochondria or to enzymatic abnormalities.  We can see greater interstitial and plasma concentrations of lactate in patients with chronic widespread pain/FMS. Importantly, the concentration of lactate correlated with pain thresholds and pain intensity – demonstrating a link between disturbed oxidative energy metabolism and chronic pain. High dose thiamine when combined with cofactors including magnesium at therapeutic dose can have substantial reduction in pain and associated symptoms of fibromyalgia.

Autonomic dysfunction can precipitate symptoms of psychological distress without the factors typically associated with psychological stressors.  Anxiety, depression, psychosis, or other disordered cognitive function can be symptoms associated with dysautonomia.

Thiamine and magnesium can work for other health issues?

• fatigue in inflammatory bowel diseases,

• post-stroke fatigue,

• fatigue in multiple sclerosis,

• fatigue in thyroiditis disease,

• fibromyalgia,

• spinocerebellar ataxias,

• Friedreich ataxia,

• Steinert disease (muscular dystrophy),

• dystonia,

• essential tremor,

• cluster headache, and

• migraine.

Training Your Respiration.

The diaphragm is the primary muscle responsible for respiration. As we age this muscle gets weaker which decreases our ability to inhale and exhale.

The flow of air in and out of the alveoli is called ventilation and has two stages: inspiration (or inhalation) and expiration (or exhalation). High-resistance inspiratory muscle strength training (IMST) combined with targeted nutritional supplements can support reduction of pain and low oxygen states. IMST involves taking deep breaths through a handheld resistance device. Taking time to re-train the body to take deeper breaths from the diaphragm allows us to intake a greater volume of oxygen which gives us more energy and ultimately translates to better overall health and normal blood pressure.

Mitochondrial oxygen consumption results in the critically important production of ATP – cellular energy. Without oxygen, no ATP. Without ATP, nothing works. Cells die. Tissues die. Organs fail. Whether and how quickly injury or death ensues is determined by a number of factors, including the totality of the oxygen deprivation, but also, the metabolic flexibility to withstand insufficient oxygenation, even at low levels.

Diaphragmator instructions

Insert the mouthpiece in your mouth with the engraved word “top” at the base of the mouthpiece facing up. Bite down the inner sides of the mouthpiece to hold it in place.

Breathe in and out while adjusting the resistance valve to select your desired level of breathing resistance (make it challenging, but not uncomfortable). Turn the valve to the left for more resistance (+), and turn it to the right for less (-). Once you have set your desired level of resistance, do the following three-step exercise without taking the mouthpiece out of your mouth.

Inhale through the mouthpiece slowly, as deeply as you can.

Hold your breath for a couple of seconds.

Exhale through the mouthpiece slowly until you’re almost out of breath.

Then repeat the above exercise 10 times to complete one set. Do 2 to 4 sets per day, preferably before any meals.

For athletes, do an additional set right before you start any sport or physical activity (Walk, Run, Swim, Bike, Row, Dive. Etc.) This is a great warm-up exercise!

NOTE: Do this exercise in a well-ventilated area. Do not do this exercise if you smoke.

Do not share the use of your unit with another person. If you have any medical condition, consult your physician about doing this exercise for your specific condition.

Levels of nitric oxide increased.

There is also evidence of benefits to cognitive, cardiovascular, and sports performance with a regiment of 30 high-resistance inhalations per day for six days.

Obstructive sleep apnea

Dysphagia is a medical term used to describe difficulty swallowing.  (IMST) has been shown to improve dysphagia.

Reduce stress and anxiety

Studies have shown that deep breathing can help lower your resting heart rate, and relax the mind.  Deep breathing calms the parasympathetic nervous system which some researchers feel can boost the metabolism.

Improve endurance and performance

Athletes in most sports could improve their performance by undergoing respiratory muscle training.

Product RecommendationProduct FeaturesDosing
DiaphragmatorTaking time to re-train the body to take deeper breaths from the diaphragm allows us to intake a greater volume of oxygen which gives us more energy and ultimately translates to better overall health and normal blood pressure.5 minutes morning and night
Elements SprayA transdermal magnesium spray that allows increased absorption through the skin.  Great on sore muscles, joints and cramps.20 – 30 sprays over a large body surface area
Magnesium BisglycinateSupport healthy magnesium status to support sleep, positive mood, and relaxation.  Magnesium is responsible for 3751 essential enzyme functions and over 300 metabolic functions in the body. Elevated level of calcium in the arteries is a common denominator in hypertension and when calcium enters the cell it reduces energy.  Calcium should always be extracellular and magnesium intercellular.  Magnesium acts as a natural calcium channel blocker.  Calcium levels are brought down as magnesium levels increase.  Magnesium is essential for maintaining the elasticity and structural integrity of blood vessels.  If you suffer from fatigue, you can be assured that you are magnesium deficient.Capsules: 1 capsule in between breakfast, lunch, and dinner. 1 – 3 capsules per day in divided doses. 5 mg per pound of body weight   200 mg per capsule  
Metabolic FormulaBecause no micronutrient works on its own the Metabolic Formula should always be used with therapeutic doses of thiamin and magnesium. Metabolic Formula contains bioactive vitamins, minerals and cofactors to enhance absorption and utilization of thiamine.1 to 2 capsules per day with meals
Superior Source B-1 MicroLingualWithin 30 days in most of the cases, a clear and appreciable improvement of the symptoms is detected by the patient. A further improvement is observed within the following two to three months. If high oral doses of thiamine are taken later during the day (evening or night) there may be difficulties in falling asleep. Thiamine is highly effective with all symptoms, both motor and non-motor ones. In Parkinson’s motor symptoms are tougher to eliminate and do require the addition of adequate doses of L-dopa which are made incredibly more effective by the high-dose thiamine protocol though.Dissolve 1 MicroLingual tablet under the tongue every other day prior to 1:00 in the afternoon. The right dose is always tailored to the specific characteristics of the patient: weight, duration of the disease, severity of the symptoms.  The “right dose” is found when the disturbed balance is suppressed and the patient regains normal balance. In other words, the right dose is the one which normalizes the pull-test in Parkinson’s.  If symptoms like jittery appear at the beginning of the treatment, this may mean that such dose of thiamine is already too high for the needs of the specific patient.

Eliminate: calcium, and iron supplements.

  • Optimize your diet — Avoid foods that tax your immune systems, such as trans fats, seed oils, high fructose corn syrup, fried foods, processed foods, sugars, GMOs, and grains. Seek to reduce your net carbohydrate (sugar, grains, fructose) and protein intake, replacing them with high-quality healthy fats. 
  • Donate blood 3 to 4 times per year – For men and post-menopausal women, donating blood every 3 months will relieve the burden of excess unbound iron.  Be sure to donate whole blood, not plasma, platelets, or power red.  Every time you donate blood you eliminate 250 mg of iron.  Donating blood improves liver function, and reduces, heart attack, stroke, cholesterol, and cancer risks.
  • Balance your gut flora — One of the best ways to support your gut is by incorporating Colavocado Yogurt, Biome ReBoot, and naturally fermented foods into your diet.
  • Exercise regularly — Exercise improves the circulation of immune cells in your blood, creating a more efficient system for locating and eliminating pathogens in your body. Make sure your fitness plan incorporates weight training, high-intensity exercises, stretching, and core work.
  • Get plenty of restorative sleep — Research shows sleep deprivation has the same effect on your blood pressure as physical stress or disease, which is why you may feel ill after a sleepless night.
  • Reduce Stress — High levels of stress hormones can diminish your immunity increase blood pressure and crash magnesium levels so be sure you’re implementing some sort of stress management. 

The contents of this document and the opinions expressed are for educational purposes only.  This document is not intended to replace medical advice, nor to diagnose or treat any disease, condition, illness, or injury.  It is important that prior to beginning any diet or exercise program including any aspect of the WellvilleSpa program, you receive full medical clearance from a licensed medical professional.  The information provided is for the sole use of our WellvilleSpa members and is not to be shared with the general public.

Revised 2/25/2023

Just Breathe Intro

1 – 12 oz. Elements Spray           1 – Magnesium Bisglycinate (60)

1 – Metabolic Formula (90)        1 – Diaphramator                    

1 – Superior Source B-1 MicroLingual (60)

For more information 518 899-5310

Symptom improvement chart

Non-Motor Symptoms

Anxiety reduced or eliminated                       □ Depression reduced or eliminated

□ Mood improved                                                 □ Willingness to socialize

Cognitive ability

□ Brain fog / focus / clarity                                  □ Concentration

□ Improved memory                                             □ Return of creativity

□ Sense of smell                                                     □ Sleep Improved

Bodily Functions

□ Improved gut functions                                    □ Urinary incontinence improved

□ Constipation improved                                     □ Muscle cramps reduced


□ Fatigue reduced / increased energy             □ Quicker recovery after exercise

□ Pain eliminated                                      

Motor Symptoms


□ Gate improved / arm swing / shuffling        □ Walking speed            

Walking without cane                                       □ Leg strength

□ Dragging feet                                                       □ Stooped posture        

Postural instability

□ Balance and stability improved                      □ Push test improvements


□ Handwriting / typing / mouse usage             □ Clapping possible

□ Hand strength    


□ Bradykinesia / slow motion reduced             □ More fluid movements

□ Easier turning in bed                                         □ Getting in and out of bed easier

□ Able to rise from seated position                  □ Able to use stairs

□ Freezing reduced or eliminated                     □ Flexibility improved


□ Reduced stiffness                                               □ Masked face normalized

□ Smiling right up to the eyes                            □ Ability to exercise

□ Dystonia reduced or eliminated                     □ Toe curling reduced


□ Tremors of hands, arms and feet reduced □ Twitching reduced

□ Dyskinesia reduced

Voice and swallowing

□ Improved voice volume                                    □ Improved swallowing

□ Drooling reduced


□ Feeling of well being